Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo

Sandra Kraljević Pavelić, Vedran Micek, Ana Filošević, Darko Gumbarević, Paula Žurga, Aleksandar Bulog, Tatjana Orct, Yasuaki Yamamoto, Tajana Preočanin, Janez Plavec, Robert Peter, Mladen Petravić, Dražen Vikić-Topić, Krešimir Pavelić

“Our results add knowledge on toxicology and safety properties of clinoptilolite materials as no aluminium leakage was observed from clinoptilolite materials into the blood or organs of tested animals. Presented results therefore, prove for the first time the efficiency of clinoptilolite in detoxification of aluminium in vivo, provide scientific data on clinoptilolite safety issues and usage for detoxification purposes.”

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo.

Kraljević Pavelić S, Simović Medica J, Gumbarević D, Filošević A, Pržulj N, Pavelić K.

Commentary:

This analysis is published in the Official NIH Records.

Silicon-rich mineral water as a non-invasive test of the 'aluminum hypothesis' in Alzheimer's disease.

Samantha Davenward 1, Peter Bentham, Jan Wright, Peter Crome, Deborah Job, Anthony, Polwart, Christopher Exley https://pubmed.ncbi.nlm.nih.gov/22976072/

"Abstract: There has been a plausible link between human exposure to aluminum and Alzheimer's disease for several decades. We contend that the only direct and ethically acceptable experimental test of the ‘aluminum hypothesis’, which would provide unequivocal data specific to the link, is to test the null hypothesis that a reduction in the body burden of aluminum to its lowest practical limit would have no influence upon the incidence, progression, or severity of Alzheimer's disease. Herein we are testing the hypothesis that silicon-rich mineral waters can be used as non-invasive methods to reduce the body burden of aluminum in individuals with Alzheimer's disease and a control group consisting of their carers and partners. We have shown that drinking up to 1 L of a silicon-rich mineral water each day for 12 weeks facilitated the removal of aluminum via the urine in both patient and control groups without any concomitant affect upon the urinary excretion of the essential metals, iron and copper. We have provided preliminary evidence that over 12 weeks of silicon-rich mineral water therapy the body burden of aluminum fell in individuals with Alzheimer's disease and, concomitantly, cognitive performance showed clinically relevant improvements in at least 3 out of 15 individuals. This is a first step in a much needed rigorous test of the ‘aluminum hypothesis of Alzheimer's disease’ and a longer term study involving many more individuals is now warranted.”

Dietary zeolite supplementation reduces oxidative damage and plaque generation in the brain of an Alzheimer's disease mouse model.

Mery Montinaro 1, Daniela Uberti, Giuseppina Maccarinelli, Sara Anna Bonini, Giulia FerrariToninelli, Maurizio Memo https://pubmed.ncbi.nlm.nih.gov/23562853/